The new Clinical Trial Application for the conduct of a Phase I/II study of RVU120 (SEL120) in patients with solid tumors submitted by Ryvu Therapeutics S.A.

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Three Posters on SEL24/MEN1703 including Pharmacodynamic Data from the Dose Escalation Part of DIAMOND-01 Trial to be published at American Society of Hematology (ASH) Annual Meeting

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Appointment of the new Management Board Member of Ryvu Therapeutics S.A.

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Ryvu Therapeutics S.A. Q3 2020 Financial Report

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Revision of the Company’s research project pipeline

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Ryvu Therapeutics abstract concerning the STING program accepted for presentation at the SITC 2020

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Change of the registered office address of Ryvu Therapeutics S.A.

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First patient dosed in Europe within the Expansion Cohort of Phase I/II Clinical Study of SEL24/MEN1703

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Ryvu Therapeutics 2020 H1 Financial Report

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Appointment of Members of the Company’s Management and Supervisory Boards for a new term of office

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Shareholders controlling at least 5% of the vote at the General Meeting of Ryvu Therapeutics S.A. held on August 31, 2020

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Resolutions adopted by the Annual General Shareholders Meeting of Ryvu Therapeutics S.A.

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Introduction of the Series I Shares to trading on the main market operated by the WSE and designation of the last day of listing of Rights to Series I Shares

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Registration of share capital increase

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Completion of the subscription of Series I Shares

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Introduction of the Rights to Series I Shares to trading on the main market operated by the WSE

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Registration of the Rights to Series I Shares in the book-entry form by the National Depository for Securities

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Execution of subscription agreements and collection of cash contributions relating to series I shares in Ryvu Therapeutics S.A.

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Determination of the issue price of Series I shares issued by Ryvu Therapeutics S.A., the number of Series I shares to be offered for subscription by Ryvu Therapeutics S.A. and execution of the pricing supplement to the placement agreement

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Ryvu Therapeutics S.A. concludes a placement agreement and commences the book-building process for an offering by way of private subscription of new Series I ordinary bearer shares issued by Ryvu Therapeutics S.A.

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