- SEL120−34A, a specific, potent and orally bioavailable inhibitor of CDK8, targets STAT-dependent gene transcription in leukemia and lymphoma models, poster board: P081, abstract #402.Poster reports the most recent results in the SEL120 project, showing that SEL120-34A shows high efficacy in leukemia models in vitro and in vivo, as well that the presented novel mechanism of action of the inhibitor involves changes in STAT-dependent gene transcription linked to inflammation and differentiation. Whats more, SEL120-34A shows favorable pharmacokinetic profile and safety indicating high therapeutic potential.
- Development of selective MELK kinase inhibitors for breast cancer treatment, poster board: P132, abstract #453.Poster reports the most recent results of the program developed in cooperation with H3 Biomedicine, from Cambridge, MA.
To get in touch with Selvita delegates at 2016 EORTC-NCI-AACR Symposium, please contact us at: [email protected], or +48 12 297 47 00.